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The neurologic phenotype in SCA8 BAC enlargement but not BAC Regulate strains shown the pathogenicity on the (CTG-CAG)n expansion. Also, the expression of noncoding (CUG)n enlargement ATXN8OS transcripts and the discovery of intranuclear polyglutamine inclusions recommended that SCA8 pathogenesis consists of toxic achieve-of-perform mechanisms at b

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